WRC hotspot mutations taken from Yaari et al., Frontiers in Immunology, 2013. These include only the mutations following the WRC pattern, where W equals A or T and R equals A or G). Custom mutation hotspots can be supplied by modifying this dataframe. Repeating particular hotspot entries allows for the hotspot to mutate more than one time per SHM event.
data("one_spot_df")A data frame with 32 rows and 6 variables:
Character array where each entry corresponds to a 5 base motif. The mutation probabilities correspond to the middle nucleotide in each 5mer.
The probability for the middle nucleotide in "pattern" to mutate to an adenine
The probability for the middle nucleotide in "pattern" to mutate to an cytosine
The probability for the middle nucleotide in "pattern" to mutate to an guanine
The probability for the middle nucleotide in "pattern" to mutate to an thymine
The origin of how this motif was discovered. Either Inferred or Experimental
Yaari et al., Frontiers in Immunology, 2013